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M9460703.TXT
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1994-06-25
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Document 0703
DOCN M9460703
TI Quantitative EEG in patients with AIDS and asymptomatic HIV infection.
DT 9408
AU Newton TF; Leuchter AF; Miller EN; Weiner H; Department of Psychiatry,
Department of Veterans' Affairs Medical; Center, West Los Angeles, CA
90073.
SO Clin Electroencephalogr. 1994 Jan;25(1):18-25. Unique Identifier :
AIDSLINE MED/94228728
AB Although neuropsychiatric abnormalities are common in subjects with the
acquired immunodeficiency syndrome (AIDS), they are less frequent in
asymptomatic human immunodeficiency virus (HIV) seropositive subjects.
In contrast, others have reported high rates of electroencephalographic
(EEG) abnormality among asymptomatic subjects. Here we report clinical
and quantitative EEG findings across all stages of the disease in order
to define when during the course of illness abnormalities are
detectable. We studied 28 men with AIDS, 32 men with asymptomatic HIV
infection, and 56 uninfected controls using clinical and quantitative
EEG, measures of immunosuppression, and tests of neuropsychological
performance. All were gay or bisexual without other significant risk
factors for encephalopathy. We found very low rates of clinical EEG
abnormality (less than 7%) among the asymptomatic HIV-infected group, a
rate comparable to those of the uninfected group (7.1%). There were no
differences between asymptomatic HIV-seropositive subjects and
uninfected controls on quantitative EEG measures. Among AIDS patients
28.6% had abnormal clinical electroencephalograms. On quantitative
measures, the greatest differences were found in the 6-10 Hz band, where
AIDS patients had consistently increased absolute power, relative power,
and coherence compared to the uninfected and asymptomatic seropositive
groups. A subgroup (n = 9) of asymptomatic HIV-seropositive subjects had
worsening performance on Trailmaking test, part B, at or after the time
of recording. This subgroup had quantitative electroencephalographic
measures similar to those of the AIDS patients and different from the
remainder of the asymptomatic HIV-seropositive group.(ABSTRACT TRUNCATED
AT 250 WORDS)
DE Adult AIDS Dementia Complex/DIAGNOSIS/*PHYSIOPATHOLOGY Bisexuality
Brain Mapping Cerebral Cortex/PHYSIOPATHOLOGY
Electroencephalography/*CLASSIFICATION/INSTRUMENTATION Homosexuality
Human HIV Seropositivity/DIAGNOSIS/*PHYSIOPATHOLOGY Male
Microcomputers Middle Age Signal Processing,
Computer-Assisted/INSTRUMENTATION Support, Non-U.S. Gov't Support,
U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).